Description:
Nanocs SnapLink maleimide PEG NHS is a pegylated, amine and sulfhydryl reactive crosslinker. This crossliker is non-cleavable and water soluble. It contains an amine reactive, NHS ester and a sulfhydryl reactive maleimide group linked with polyethylene glycol of different length. The hydrophilic polyethylene glycol (PEG) spacer arm imparts water solubility that is transferred to the crosslinked molecules , thus reducing aggregation of labeled proteins in solution. The PEG spacer arm also gives the maleimide NHS a long and flexible structure to minimize steric hindrance for its reaction to other molecues. NHS esters react with deprotonated primary amines in pH 7-9. The maleimide group reacts with thiol groups at pH 6.5~7.5 to form stable thioether bonds.
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Nanocs Inc.是全球领先的PEG修饰剂(PEG derivatives, PEGylation试剂)供应商,拥有种类齐全的PEG衍生物,包括:NHS-PEG,马来酰亚胺PEG,巯基PEG,氨基PEG,叠氮PEG,DSPE PEG,荧光PEG等。为全世界数以百万计的客户提供产品与服务。修饰性PEG可应用于药物输送、医疗设备改造和诊断分析等领域。Nanocs提供从磷脂PEGs到荧光PEGs的多种选择,种类齐全,产品线丰富。